Fourth seed Kiki Bertens retired from her French Open second-round match against Viktoria Kuzmova with illness.
Bertens, one of the favourites for the title, was 3-1 behind in the first set when she called for the doctor, saying she had no energy and felt shaky.
The Dutch Woman won the Madrid Open on 11 May, beating 2018 French Open champion Simona Halep in the final.
Kuzmova will play either Britain's Johanna Konta or Lauren Davis of the United States in the third round.
Earlier, world number two Karolina Pliskova continued her bid for a first Grand Slam with a routine win over Kristina Kucova.
The big-serving Czech won 6-2 6-2 against the world number 203 in just 56 minutes.
Pliskova hit 25 winners and six aces as she maintained the strong clay-court form that saw her win the Italian Open in the run-up to Roland Garros.
Sloane Stephens and Garbine Muguruza also both progressed to the third round with straight-set wins.
Karolina Pliskova's best Grand Slam performance came in 2017 when she was runner-up at the US Open
American seventh seed Stephens, last year's runner-up, beat Spanish world number 75 Sara Sorribes Tormo 6-1 7-6 (7-3).
Muguruza, the 2016 French Open champion, won 6-4 6-1 against 172-ranked Johanna Larsson of Sweden.
The Spaniard will play ninth seed Elina Svitolina in the third round after the Ukrainian received a walkover when compatriot Kateryna Kozlova pulled out.
Pliskova meets Petra Martic while Stephens plays Polona Hercog.
Elsewhere, 22nd seed Bianca Andreescu of Canada pulled out for her second-round match with American Sofia Kenin, scheduled for Thursday, because of injury.
Kenin will meet the winner of Thursday's second-round match between Serena Williams and Kurumi Nara.