Andre Agassi says he and Novak Djokovic "agreed to disagree" too often and he has left the former world number one's coaching team.
Eight-time Grand Slam champion Agassi, 47, became Djokovic's head coach last May.
The 30-year-old Serb has struggled to rediscover his 12-time Grand Slam title-winning form following a lengthy setback with an elbow injury.
"I wish him only the best moving forward," American Agassi said.
"With only the best intentions, I tried to help Novak. We far too often found ourselves agreeing to disagree."
The split means the only coach in Djokovic' team is Czech former world number eight Radek Stepanek, who joined part-time in November 2017.
After completing a career slam with victory at the French Open in 2016, Djokovic has suffered a dramatic decline in form and was unable to retain his title at Roland Garros last year, before retiring injured in the Wimbledon quarter-finals.
After having more surgery on his elbow following the Australian Open, he returned to court last month but fell to successive first-round defeats at Indian Wells and the Miami Open.
A former tennis pro and compatriot of Novak Djokovic has slated Andre Agassi following his brief stint as the Serbian's coach.
In a brutally honest interview with with Tennis World USA,Radmilo Armenulic accused Agassi of not knowing what to do to improve Djokovic's game, adding that the split was long overdue.
“I was opposed to that co-operation since the first day because he didn't do anything for Novak,” said Armenulic.
“I think Novak helped him more because he made Agassi a coach.
“He left because he didn't know what to do.
“He never worked as a coach and had no experience how to help Novak.
“Novak plays from the baseline better than Agassi and his return is better.
“Then how can Agassi help him?”